We built an efficient genome-wide association pipeline to test thousands of potential associations between genomics and proteomics datasets from cancer patients.

This revealed that copy-number changes are frequently post-transcriptionally attenuated at the protein level and particularly noticeable in protein complexes where copy-number alterations are buffered by co-regulation of subunits abundance. This study showed the broad implications of post-transcriptional regulation in cancer and, despite their high frequency, 23%-33% of the observed copy-number alterations are buffered.

More recently, we reported the importance of protein interfaces to regulate these interactions.

Kim, Eiru, and Traver Hart. 2017. “All for One, and One for All.” Cell Systems. Elsevier.

Reference

Gonçalves, Emanuel, Athanassios Fragoulis, Luz Garcia-Alonso, Thorsten Cramer, Julio Saez-Rodriguez, and Pedro Beltrao. 2017. “Widespread Post-Transcriptional Attenuation of Genomic Copy-Number Variation in Cancer.” Cell Systems 5 (4): 386–98.e4.