We showed that abnormal accumulation of fumarate leads to epigenetic alterations eliciting epithelial-to-mesenchymal transition (EMT) and is associated with aggressive tumour features. This showcased for the first time fumarate as an oncometabolite.
We showed that abnormal accumulation of fumarate leads to epigenetic alterations eliciting epithelial-to-mesenchymal transition (EMT) and is associated with aggressive tumour features. This showcased for the first time fumarate as an oncometabolite.