Our research group focuses on developing computational approaches to analyze high-throughput drug and genetic screens, along with multi-omics datasets, to study the fundamental regulatory mechanisms underlying cancer cell response to treatments. Working closely with experimental and clinical groups, we develop integrative approaches to address one of the most pressing challenges in cancer: drug resistance.
We aim to develop the next generation of multidisciplinary engineers who can bridge the fields of computer science, cell biology, and biomedicine.
Machine Learning | Multi-omics | Functional Genomics | Drug resistance | Cancer
We developed a computational approach to correct copy-number driven deleterious bias induced by Cas9 double-strand...
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Copy Number Buffering in Cancer
Widespread post-transcriptional attenuation of genomic copy-number variation in cancer
We built an efficient genome-wide association pipeline to test thousands of potential associations between genomics...
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Oncometabolite Fumarate
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
We showed that abnormal accumulation of fumarate leads to epigenetic alterations eliciting epithelial-to-mesenchymal transition (EMT)...
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