José Paulo Sequeira Farinha


Department of Chemical Engineering
Instituto Superior Técnico
University of Lisbon

Av. Rovisco Pais 1
1049-001 Lisboa, Portugal

phone: (+351) 218 419 221

email: farinha @




Research Interests



Articles in Refereed International Journals




Biotin-End-Functionalized Highly Fluorescent Water-Soluble Polymers
Relogio,P.; Bathfield, M.; Haftek-Terreau, Z.; Beija, M.; D’Agosto, F.; Favier, A.; Giraud-Panis, M.-J.; Mandrand, B.; Farinha, J. P. S.*.; Charreyre, M.-T.;* Martinho, J. M. G.,
Polym. Chem., 2013, 4, 2968–2981.

The cover image is a reproduction of the painting "Lucifer Yellow" by Ana Tristany. Four polymer chains (blue) labeled with several LY fluorophores (yellow), each with a biotin at one chain-end (blue/black) interact with a streptavidine protein (red).


Resonance Energy Transfer in Polymer Nanodomains (Review Article)
Martinho, J. M. G.; Farinha, J. P. S.,
Journal of Physical Chemistry C, 2008, 112, 10591-10601.

The cover is a reproduction of the painting "Interfaces" (acrylic on canvas, 1.5 m x 1.5 m) by Ana Tristany. Nano-size domains located at the interface between different polymers (in black and grey) are labeled with energy donor (red) and acceptor (green) dyes

  Temperature-responsive fibers of cellulose-based copolymers
Santos, A. C.; Alves, S.; Godinho, M. H.; Baleizão, C.;* Farinha, J. P. S. *
Polymer Chemistry, 2018, 9, 3615–3623

Temperature-responsive electrospun fibers obtained from cellulose acetate grafted with a temperature-responsive random copolymer prepared by RAFT.
The prepared fiber mats target applications in temperature-responsive scaffolds for cell culture.

over image based on the painting "Blue Lines I" by Ana Tristany. 

Smart Materials for Boron Removal
Alves,S.; Santos,C.I.; da Costa,A.P.; Silva,M.; Baleizão*,C.; Farinha,J.P.S.*
Chemical Engineering Journal
2017, 319, 31–33

The cover shows a novel boron scavenging process. At room temperature the nanoparticlesare expanded, promoting boron chelation to diol groups. At higher temperature the polymer shell collapses inducing nanoparticle flocculation. The nanoparticles can then be regenerated by pH treatment and reused. 

A Cationic Smart Copolymer for DNA Binding
Ribeiro,T.; Santiago,A.M.; Martinho,J.M.G.; Farinha,J.P.S.*
Polymers 2017, 11, 576

A new copolymer with a temperature-responsive block and a cationic block forms coacervate complexes with the DNA. The new materials offer good prospects for application in controlled gene delivery.

  Temperature-Responsive Copolymers without Compositional Drift by RAFT Copolymerization of 2-(Acryloyloxy)ethyl trimethylammonium chloride and 2-(Diethylamino)ethyl acrylate
Rodrigues, A.S.; Charreyre, M.-T.*; Favier, A.; Baleizão, C.; Farinha, J. P. S. *
Polymer Chemistry, 2019, 10, 2106–2116

The cover image depicts new remarkable temperature and pH responsive copolymers based on [2-(acryloyloxy)ethyl] trimethylammonium chloride (AEtMACl) and protonated 2-(diethylamino)ethyl acrylate (DEAEA+), featuring RAFT copolymerization kinetics with both apparent reactivity ratios of about 1, that allow the preparation of copolymers with controlled molecular weight and highly homogeneous composition.
Hydrogels of these copolymers have been previously selected for their excellent performance in releasing cultured stem cells using only a mild temperature stimulus.
The new materials offer exciting opportunities for application in controlled delivery, tissue engineering, separation, etc.

Cover image based on the triptic "Connection & Dissension" by Ana Tristany.


Post-doctoral fellow at the Department of Chemistry of the University of Toronto, Canada (Colloid and Polymer Chemistry Group, M. A. Winnik, 1997 - 1999)
PhD on Chemical Engineering (Technical University of Lisbon, 1996)
Graduated in Chemical Engineering (Instituto Superior Técnico, 1990)

Research Interests

Major Fields of Interest

Research and development of novel advanced functional materials, in particular nanostructured materials, featuring significant interaction with light, with applications in the energy, biomedical and environmental fields.


Key areas:

- Functinal nanomaterials;

- Nanoparticles;

- Polymers and Colloids;

- Emulsion and miniemulsion polymerization;

- Controled radical polymerization;

- Polymer coatings;

- Optical sensor nanomaterials;

- Fluorescence applications and laser scanning microscopy.


Nanomaterials for Imaging and Diagnostics

The use of fluorescent molecules is currently the most common labelling technique in biosensing and bioimaging for the detection of disease biomarkers.

Multifunctional Hybrid Nanoparticles encapsulating fluorophores yield high brightness photostable labels for biosensing and laser scanning microscopy. The particles can be surface-decorated with sensor and/or cancer tissue/cell targeting groups.



RSC Advances 2013, 3, 9171-9174 (

Dyes and Pigments, 2014, 110, 227-234 (


Bio-functionalyzed highly fluorescent polymers for biodyagnostics and tumor highlighting during surgery.


Polymer Chemistry 2013, 4, 2968-2981 (




Smart Nanoparticles

Stimuli-responsive nanoparticles for biomedical and environmental aplications diagnosis and separation


Phys. Chem. Chem. Phys. 2016, 18, 31711-31724 (

Langmuir, 2015, 31 , 4779-4790 (

J. Phys. Chem. B, 2014, 118, 3192−3206 (

Langmuir 2013, 29, 13821-13835 (

Langmuir 2012, 28, 5802-5809 (


Polymer 2017, 116, 261-267 (


Detection of DNA hybridization

ChemPhysChem 2010, 11, 1749-1756 (

Pure and Applied Chem. 2009, 81, 1615-1634 (

J. Phys. Chem. C 2008, 112, 16331 (


Antibody separation with magnetic polymer nanoparticles

Biotechnology J. 2013, 8, 709-717 (


Boron scavenging


Chemical Engineering Journal 2017, 319, 31–33 (

Materials and Design 2018, 141, 407–413 (

Nanostructured Hybrid Aerogel Insulation

Novel sol-gel route to prepare monolithic hybrid silica/polymer aerogels, stable under atmospheric conditions

J. Materials Chemistry 2007, 17, 2195 (
Chemistry of Materials 2007, 19, 2603 (
Langmuir 2007, 23, 5727 (

Flexible hybrid aerogels prepared under Subcritical conditions.

J. Materials Chemistry A 2013, 1, 12044-12052 (

Hierarchical Nanomaterials for Structural Color

Recently funded project for the design of low-cost, non-toxic structural color pigments. These non-fading environment-friendly dyes are intended for application in reflective full-color displays, printing, coatings, cosmetics, etc.

Structural color is profusely found in nature, originating from the interaction of light with periodically arranged structures of dielectric materials in length-scales ca. half the wavelength of visible light .


European Polymer Journal 2019 113 349–356 (


Materials for Theranostics

Mesoporous Hybrid Nanoparticles (MSNs) with well-defined and controllable pore and particle morphologies can carry huge drug payloads. Covalently-linked fluorophores aligned on the pore walls for imaging and a biocompatible stimuli-responsive polymer-based gate system for controlled drug release. The polymeric shell can be modified with dyes, sensor molecules and tumor-targeting ligands (e.g., oligopeptides with RGD motif, folic acid, etc.).




Eur. J. Inorg. Chem., 2015 (

Microscopy and Microan., 2013, 19, 1216-1221 (

Nanomedicine, 2015 (
Nanoscale 2017, 36, 13485-13494 (



High Performance Coatings

Hybrid silica-polymer nanoparticles for high-performance environmentally friendly polymer coatings


Materials, 2014, 7, 3881-3900 (

CoatingsTech 2013, 10, 46-53 (ISSN 1547-0083, coatingstech/201309#pg44)



J. Phys. Chem. C 2009, 113, 18082-18090 (

J. Coll. Int. Sci. 2013, 401, 14-22 (

Langmuir 2014, 30, 12345-12353 (
J. Coll. Int. Sci.2012, 368, 21-33 (



Optical sensors

Development of new optical fluorescent sensors supported in polymers and nanoparticles

Journal of Materials Chemistry 2010, 20, 1192-1197 (



New optical sensors for Boron detection in water


Analytical Methods, 2014, 6, 5450-5453 (

RSC Advances 2017, 7, 4627 (



Metal Nanoparticle Enhanced Emission

Metal NPs act as nanoantennas when they are excited by light in resonance with their characteristic plasmon modes, and can enhance the emission of nearby fluorophores

Micellar assemblies of quantum dots and metal nanoparticles


J. Phys. Chem. C 2013, 117, 3122-3133 (

Langmuir 2017, 33, 8201-8212 (


Core-shell gold-silica nanoparticles surface-decorated with fluorophores


Nature Scientific Reports 2017, 7, 2440 (



Coordination of the Integrated MSc program in Materials Engineering, IST

Scientific Commission of the Integrated MSc program in Biomedical Engineering, IST



Nanostructured Materials and Nanotechnology (Master program in Materials Engineering)

Polymeric Materials (Master program in Materials Engineering)

Surfaces, Interfaces and Colloids (PhD programs, Master program in BioEngineering and Nanosystems)

Advanced Topics in Nanotechnology (PhD program in Materials Engineering)

Materials for Regenerative Medicine (FCT PhD program in Bioengineering – Cell Therapies and Regenerative Medicine

Chemical Engineering Lab (Master program in Chemical Engineering)

Project I & II (Master program in Chemical Engineering)

Physical Chemistry (Master programs in Biological Engineering and in Chemical Engineering)

General Chemistry


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