We presented one of the largest CRISPR-Cas9 screens available to date, and developed a precision oncology target prioritisation pipeline which screened 324 cancer cell lines and reported for the first time a synthetic-lethal interaction between microsatellite instability and WRN helicase.


Behan, Fiona M., Francesco Iorio, Gabriele Picco, Emanuel Gonçalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, et al. 2019. “Prioritization of Cancer Therapeutic Targets Using CRISPR-Cas9 Screens.” Nature 568 (7753): 511–16.